If you need the or a step-by-step guide for FEX-Emu on Windows (since it’s Linux-native), let me know, and I’ll adapt the story into a direct tutorial.
It is also worth checking for the latest official Naughty Dog patches. While they haven't completely removed the instruction set requirement for everyone, recent updates have improved compatibility for a wider range of legacy hardware. However, for those on truly unsupported platforms, the community "uncharted 4 avx2 fix new" remains the gold standard for getting Nathan Drake’s final adventure up and running.