The 2022 live-action film (also known as Hagane no Renkinjutsushi: Kanketsu-hen - Fukushuusha Scar ) is the high-stakes sequel to the 2017 original. As the first part of the "Final Chapter" duology, it brings the intense battle between the Elric brothers and the mysterious vigilante Scar to life.

The story opens with Scar hunting down a rogue State Alchemist, known as the "Gold-Toothed Doctor's apprentice," who is continuing human transmutation experiments in secret. Edward and Alphonse, chasing rumors of a Philosopher's Stone, stumble upon the same laboratory. There, they discover Ishvalan refugees being used as live sacrifices — their life force slowly drained to fuel a failed Stone.